ATP8A1 Back

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

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NCBI Description of ATP8A1

The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP8A1 is highly significantly mutated in
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ATP8A1 is significantly mutated in
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ATP8A1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ATP8A1