ATP6V0A1 Back

ATPase, H+ transporting, lysosomal V0 subunit a1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ATP6V0A1
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ATP6V0A1 Add / Edit ATP6V0A1: Annotations

No community annotations yet for ATP6V0A1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP6V0A1 is highly significantly mutated in
(none)
ATP6V0A1 is significantly mutated in
(none)
ATP6V0A1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ATP6V0A1