ATP5A1 Back

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ATP5A1
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16.

Community Annotation of ATP5A1 Add / Edit ATP5A1: Annotations

No community annotations yet for ATP5A1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP5A1 is highly significantly mutated in
(none)
ATP5A1 is significantly mutated in
(none)
ATP5A1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ATP5A1