ATP2A3 Back

ATPase, Ca++ transporting, ubiquitous

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NCBI Description of ATP2A3
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP2A3 is highly significantly mutated in
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ATP2A3 is significantly mutated in
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ATP2A3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ATP2A3