ATP1B4 Back

ATPase, (Na+)/K+ transporting, beta 4 polypeptide

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NCBI Description of ATP1B4

This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATP1B4 is highly significantly mutated in
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ATP1B4 is significantly mutated in
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ATP1B4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ATP1B4