ATG4A Back

ATG4 autophagy related 4 homolog A (S. cerevisiae)

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NCBI Description of ATG4A
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.

Community Annotation of ATG4A Add / Edit ATG4A: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ATG4A is highly significantly mutated in
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ATG4A is significantly mutated in
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ATG4A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ATG4A