ATF2 Back

activating transcription factor 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ATF2

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.

Community Annotation of ATF2 Add / Edit ATF2: Annotations

No community annotations yet for ATF2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ATF2 is highly significantly mutated in
ATF2 is significantly mutated in
ATF2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ATF2