ASPM Back

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

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NCBI Description of ASPM

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ASPM Add / Edit ASPM: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ASPM is highly significantly mutated in
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ASPM is significantly mutated in
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ASPM is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ASPM