ASGR2 Back

asialoglycoprotein receptor 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ASGR2
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of ASGR2 Add / Edit ASGR2: Annotations

No community annotations yet for ASGR2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ASGR2 is highly significantly mutated in
(none)
ASGR2 is significantly mutated in
(none)
ASGR2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ASGR2