ASAH2 Back

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

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NCBI Description of ASAH2
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ASAH2 is highly significantly mutated in
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ASAH2 is significantly mutated in
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ASAH2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ASAH2