ARPC1A Back

actin related protein 2/3 complex, subunit 1A, 41kDa

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NCBI Description of ARPC1A
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ARPC1A Add / Edit ARPC1A: Annotations

No community annotations yet for ARPC1A.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARPC1A is highly significantly mutated in
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ARPC1A is significantly mutated in
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ARPC1A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARPC1A