ARMC10 Back

armadillo repeat containing 10

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NCBI Description of ARMC10
This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.

Community Annotation of ARMC10 Add / Edit ARMC10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARMC10 is highly significantly mutated in
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ARMC10 is significantly mutated in
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ARMC10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARMC10