ARL6 Back

ADP-ribosylation factor-like 6

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NCBI Description of ARL6
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.

Community Annotation of ARL6 Add / Edit ARL6: Annotations

No community annotations yet for ARL6.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARL6 is highly significantly mutated in
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ARL6 is significantly mutated in
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ARL6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARL6