ARL2BP Back

ADP-ribosylation factor-like 2 binding protein

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NCBI Description of ARL2BP
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.

Community Annotation of ARL2BP Add / Edit ARL2BP: Annotations

No community annotations yet for ARL2BP.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARL2BP is highly significantly mutated in
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ARL2BP is significantly mutated in
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ARL2BP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARL2BP