ARHGEF7 Back

Rho guanine nucleotide exchange factor (GEF) 7

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ARHGEF7
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of ARHGEF7 Add / Edit ARHGEF7: Annotations

No community annotations yet for ARHGEF7.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGEF7 is highly significantly mutated in
(none)
ARHGEF7 is significantly mutated in
(none)
ARHGEF7 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGEF7