ARHGEF6 Back

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

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NCBI Description of ARHGEF6
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGEF6 is highly significantly mutated in
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ARHGEF6 is significantly mutated in
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ARHGEF6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGEF6