Rho guanine nucleotide exchange factor (GEF) 5

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NCBI Description of ARHGEF5

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

Community Annotation of ARHGEF5 Add / Edit ARHGEF5: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ARHGEF5 is highly significantly mutated in
ARHGEF5 is significantly mutated in
ARHGEF5 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ARHGEF5