ARHGEF2 Back

rho/rac guanine nucleotide exchange factor (GEF) 2

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NCBI Description of ARHGEF2
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of ARHGEF2 Add / Edit ARHGEF2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGEF2 is highly significantly mutated in
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ARHGEF2 is significantly mutated in
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ARHGEF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGEF2