ARHGEF15 Back

Rho guanine nucleotide exchange factor (GEF) 15

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NCBI Description of ARHGEF15
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene.

Community Annotation of ARHGEF15 Add / Edit ARHGEF15: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGEF15 is highly significantly mutated in
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ARHGEF15 is significantly mutated in
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ARHGEF15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGEF15