ARHGEF1 Back

Rho guanine nucleotide exchange factor (GEF) 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ARHGEF1
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Community Annotation of ARHGEF1 Add / Edit ARHGEF1: Annotations

No community annotations yet for ARHGEF1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGEF1 is highly significantly mutated in
(none)
ARHGEF1 is significantly mutated in
(none)
ARHGEF1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGEF1