ARHGAP8 Back

Rho GTPase activating protein 8

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NCBI Description of ARHGAP8
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Community Annotation of ARHGAP8 Add / Edit ARHGAP8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGAP8 is highly significantly mutated in
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ARHGAP8 is significantly mutated in
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ARHGAP8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGAP8