ARHGAP6 Back

Rho GTPase activating protein 6

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NCBI Description of ARHGAP6

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ARHGAP6 Add / Edit ARHGAP6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGAP6 is highly significantly mutated in
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ARHGAP6 is significantly mutated in
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ARHGAP6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ARHGAP6