ARHGAP27 Back

Rho GTPase activating protein 27

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NCBI Description of ARHGAP27
Rho (see ARHA; MIM 165390)-like small GTPases are involved in many cellular processes, and they are inactive in the GDP-bound state and active in the GTP-bound state. GTPase-activating proteins, such as ARHGAP27, inhibit Rho-like proteins by stimulating their intrinsic GTPase activity (Katoh and Katoh, 2004 [PubMed 15492870]).[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARHGAP27 is highly significantly mutated in
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ARHGAP27 is significantly mutated in
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ARHGAP27 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARHGAP27