Rho GTPase activating protein 22

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NCBI Description of ARHGAP22

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ARHGAP22 Add / Edit ARHGAP22: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ARHGAP22 is highly significantly mutated in
ARHGAP22 is significantly mutated in
ARHGAP22 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ARHGAP22