Rho GTPase activating protein 12

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NCBI Description of ARHGAP12

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of ARHGAP12 Add / Edit ARHGAP12: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ARHGAP12 is highly significantly mutated in
ARHGAP12 is significantly mutated in
ARHGAP12 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ARHGAP12