ARFGEF2 Back

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

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NCBI Description of ARFGEF2

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of ARFGEF2 Add / Edit ARFGEF2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARFGEF2 is highly significantly mutated in
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ARFGEF2 is significantly mutated in
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ARFGEF2 is near significance in
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Data details


Mutation list for ARFGEF2