ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ARFGEF1

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition.

Community Annotation of ARFGEF1 Add / Edit ARFGEF1: Annotations

No community annotations yet for ARFGEF1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ARFGEF1 is highly significantly mutated in
ARFGEF1 is significantly mutated in
ARFGEF1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ARFGEF1