ARFGEF1 Back

ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)

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NCBI Description of ARFGEF1
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARFGEF1 is highly significantly mutated in
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ARFGEF1 is significantly mutated in
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ARFGEF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARFGEF1