AREG Back

amphiregulin (schwannoma-derived growth factor)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AREG

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.

Community Annotation of AREG Add / Edit AREG: Annotations

No community annotations yet for AREG.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AREG is highly significantly mutated in
(none)
AREG is significantly mutated in
(none)
AREG is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for AREG