ARAP3 Back

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

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NCBI Description of ARAP3
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARAP3 is highly significantly mutated in
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ARAP3 is significantly mutated in
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ARAP3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARAP3