ARAP1 Back

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ARAP1
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ARAP1 Add / Edit ARAP1: Annotations

No community annotations yet for ARAP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ARAP1 is highly significantly mutated in
(none)
ARAP1 is significantly mutated in
(none)
ARAP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ARAP1