APPL1 Back

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

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NCBI Description of APPL1

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Community Annotation of APPL1 Add / Edit APPL1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


APPL1 is highly significantly mutated in
APPL1 is significantly mutated in
APPL1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for APPL1