APOBEC3H Back

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H

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NCBI Description of APOBEC3H
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

APOBEC3H is highly significantly mutated in
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APOBEC3H is significantly mutated in
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APOBEC3H is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for APOBEC3H