APH1B Back

anterior pharynx defective 1 homolog B (C. elegans)

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NCBI Description of APH1B
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.

Community Annotation of APH1B Add / Edit APH1B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

APH1B is highly significantly mutated in
(none)
APH1B is significantly mutated in
(none)
APH1B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for APH1B