APEX2 Back

APEX nuclease (apurinic/apyrimidinic endonuclease) 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of APEX2
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of APEX2 Add / Edit APEX2: Annotations

No community annotations yet for APEX2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

APEX2 is highly significantly mutated in
(none)
APEX2 is significantly mutated in
(none)
APEX2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for APEX2