AP4E1 Back

adaptor-related protein complex 4, epsilon 1 subunit

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AP4E1

This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of AP4E1 Add / Edit AP4E1: Annotations

No community annotations yet for AP4E1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AP4E1 is highly significantly mutated in
(none)
AP4E1 is significantly mutated in
(none)
AP4E1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for AP4E1