AP1S1 Back

adaptor-related protein complex 1, sigma 1 subunit

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NCBI Description of AP1S1

The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AP1S1 is highly significantly mutated in
AP1S1 is significantly mutated in
AP1S1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AP1S1