ANKRD12 Back

ankyrin repeat domain 12

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NCBI Description of ANKRD12

This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ANKRD12 is highly significantly mutated in
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ANKRD12 is significantly mutated in
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ANKRD12 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ANKRD12