ANGPTL3 Back

angiopoietin-like 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ANGPTL3
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of ANGPTL3 Add / Edit ANGPTL3: Annotations

No community annotations yet for ANGPTL3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ANGPTL3 is highly significantly mutated in
(none)
ANGPTL3 is significantly mutated in
(none)
ANGPTL3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ANGPTL3