ANGPT1 Back

angiopoietin 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ANGPT1
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of ANGPT1 Add / Edit ANGPT1: Annotations

No community annotations yet for ANGPT1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ANGPT1 is highly significantly mutated in
(none)
ANGPT1 is significantly mutated in
(none)
ANGPT1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ANGPT1