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angiogenin, ribonuclease, RNase A family, 5

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NCBI Description of ANG

The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.

Community Annotation of ANG Add / Edit ANG: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ANG is highly significantly mutated in
(none)
ANG is significantly mutated in
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ANG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ANG