ANAPC7 Back

anaphase promoting complex subunit 7

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NCBI Description of ANAPC7
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ANAPC7 Add / Edit ANAPC7: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ANAPC7 is highly significantly mutated in
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ANAPC7 is significantly mutated in
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ANAPC7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ANAPC7