ANAPC13 Back

anaphase promoting complex subunit 13

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NCBI Description of ANAPC13
This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ANAPC13 is highly significantly mutated in
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ANAPC13 is significantly mutated in
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ANAPC13 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ANAPC13