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NCBI Description of AMTN

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]. Sequence Note: removed 1 base from the 3' end that did not align to the reference genome assembly.

Community Annotation of AMTN Add / Edit AMTN: Annotations

No community annotations yet for AMTN.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AMTN is highly significantly mutated in
AMTN is significantly mutated in
AMTN is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AMTN