AMD1 Back

adenosylmethionine decarboxylase 1

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NCBI Description of AMD1
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AMD1 is highly significantly mutated in
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AMD1 is significantly mutated in
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AMD1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AMD1