ALDH1L2 Back

aldehyde dehydrogenase 1 family, member L2

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NCBI Description of ALDH1L2

This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of ALDH1L2 Add / Edit ALDH1L2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ALDH1L2 is highly significantly mutated in
ALDH1L2 is significantly mutated in
ALDH1L2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ALDH1L2