ALDH1L1 Back

aldehyde dehydrogenase 1 family, member L1

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NCBI Description of ALDH1L1

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ALDH1L1 is highly significantly mutated in
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ALDH1L1 is significantly mutated in
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ALDH1L1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ALDH1L1