AKT3 Back

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AKT3
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

Community Annotation of AKT3 Add / Edit AKT3: Annotations

No community annotations yet for AKT3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AKT3 is highly significantly mutated in
(none)
AKT3 is significantly mutated in
(none)
AKT3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AKT3