AKR7A2 Back

aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)

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NCBI Description of AKR7A2
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AKR7A2 is highly significantly mutated in
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AKR7A2 is significantly mutated in
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AKR7A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AKR7A2