NCBI Description of AKR1C2
|This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.|
Community Annotation of AKR1C2 Add / Edit AKR1C2: Annotations
No community annotations yet for AKR1C2.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.