AKAP4 Back

A kinase (PRKA) anchor protein 4

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NCBI Description of AKAP4
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AKAP4 is highly significantly mutated in
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AKAP4 is significantly mutated in
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AKAP4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AKAP4